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KMID : 0608519990050010119
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Korean Journal of Oriental Medicine
1999 Volume.5 No. 1 p.119 ~ p.131
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The Protective Effect of Herbal Medicine on PC12 Cell Induced by and 6-OHDA Neurotoxicity
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Kang Bong-Joo
Hong Seong-Gil
Cho Dong-Wuk
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Abstract
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The effect of herbal medicine on 1-methyl-4-phenylpyridinium ion and 6-hydroxydopamine (6-OHDA) mediated neurotoxicity was studied in the rat phaeochromocytoma cell line PC12. The present study was designed to test the hypothesis that herbal medicine can protect cells from neurotoxiciy caused by and 6-OHDA. Exposure of PC12 cells to 0.2 mM and 6-OHDA for 24h resulted in a 50% cell death with respect to the control cells. induced cell death was reduced by Yollyounggobondan (æÅÖÆͳÜâÓ¡), Sagunjatang (ÞÌÏÖí÷·), Palmihwan (ø¢Ú«ü¯), and Palmultang (ø¢Úª÷·)(P<0.05). However, herbal medicines did not protect cells from degeneration caused by the 6-OHDA. Yollyounggobondan, Yungmijihwangwon (ë»Ú«ò¢üÜêª), Palmihwan, and Samultang (ÞÌÚª÷·) were effective in protecting against -induced ATP loss in PC12 cells (P<0.05). Yollyounggobondan and Palmultang were effect in neurite protection against 6-OHDA treatment in differentiated PC12 cells with NGF.
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KEYWORD
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6-OHDA, PC12, Parkinson¡¯s disease, SRB, ATP
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